Health Material Tray 2 For Improving Immunity

Health material tray 2 for improving immunity

yeast β— Yeast B-glucan

Yeast β— Glucan is a water insoluble branched polymer with a main chain β— 1,3 glycoside bond, branched chain β— 1,6 glycosides are bound together, accounting for 30%~35% of the dry weight of yeast cell wall. They exist in the form of triple helix, with molecular weights ranging from tens of thousands to hundreds of thousands.

It enhances immunity by activating the immune system. Yeast β— Glucan is not hydrolyzed by acids or enzymes in the stomach and intestines, but is passed by macrophages (a kind of white blood cells that can play a broad role in protecting and strengthening the immune system) on mucous cells of the small intestine β— Glucan receptor absorption β— Glucan, which then immediately activates these cells. β— 1,3-D-glucan protects the body from possible health hazards by stimulating macrophages. Macrophages are a major group of cells involved in non-specific immunity. It can swallow foreign particles and destroy them. Macrophages also provide signals to other immune cells, such as B cells and T cells, to make them move to the place of infection. It can also produce growth factors to repair damaged tissues.

The study also showed that yeast β— Dextran can reduce the sensitivity of people to upper respiratory tract infection (Talbott 2009, Talbott 2012), and alleviate the threat of daily stress to the immune system. Meanwhile, yeast β— Glucan can increase the content of immunoglobulin A (IgA), which plays an important role in the defense of human mucosal surface infection (Lehne 2005, McFarlin 2013)

Except yeast derived β— Glucan, a glucan derived from euglena, also has the effect of enhancing immunity. yeast β— Glucan and euglena are also new food raw materials approved by the state.

Mushroom
Fungi can improve the intercellular communication by influencing the expression of cytokines in cells in vivo, thereby promoting the development of stem cells (hematopoiesis). Mushroom products mainly include Ganoderma lucidum, Cordyceps sinensis, Lentinus edodes, Tricholoma dancing (Grifola), Bioctria ochroleuca, etc.

In 2019, a study published in PLOS ONE showed that, compared with the addition effect of three separate extracts, the synergistic formula of the extracts of Tricholoma, Ganoderma lucidum and Lentinula edodes with a specific proportion can improve the immune stimulation, which is based on a study sponsored by Integria Healthcare. At present, the research has been patented. It is said that this is the first report on the synergistic immunoregulatory response of human macrophages, which is related to the a-glucan and β— Dextran content. Mushroom polysaccharides that cause immune regulation reaction are rich β— Glucan, while a-glucan content is low. Among them, a-glucan is very important for nutrition and is the main source of carbohydrate in the diet.

The research team analyzed nine commercially available preparations extracted from three kinds of mushrooms (Ganoderma lucidum, Lentinus edodes and Tricholoma dancing). be based on β— For the content of glucan and a-glucan, the researchers selected three extracts to combine into a formula. The team then evaluated the effect of each extract and formula on the expression of certain cytokines (small proteins secreted by immune cells, which are important for cell signal transduction) in human macrophages, a type of white blood cells.

The results showed that most mushroom extracts and formulations were highly effective immunostimulants. Compared with the extract alone, the mushroom formula showed enhanced efficacy in the expression of certain cytokines, indicating that the mushroom formula has potential synergistic effects.

Fucoidan

Fucoidan, also known as fucoidan and fucoidan, is an intercellular polysaccharide that exists in kelp, Undaria pinnatifida, fucoidan and other brown algae. It has a unique sulfur group and can protect the water of marine plants. Even in very harsh environments such as strong sunlight, it can still ensure the survival of marine brown algae.

Fucopolysaccharides, which have multiple health effects such as anti-oxidation and anti-cancer, have rapidly attracted attention under the promotion of Japanese research. In particular, the health and longevity of the Japanese are partly attributed to the efficacy of fucoidan. In 2006, Professor Takahisa Nakano of Kitasato University in Japan found that fucoidan can enhance the immune system of the body and use the patient's own immune system to specifically kill cancer cells. After entering the intestinal tract, fucoidan can be recognized by immune cells, generate signals to activate the immune system, activate NK cells, B cells and T cells, thus producing antibodies that bind cancer cells and T cells that kill cancer cells, specifically killing cancer cells and inhibiting the growth of cancer cells. （Planta Medica ，2006, 72, 1415.)

Curcumin

Turmeric is a plant of Zingiberaceae, and also an important herbal medicine in Ayurveda system in India. With a history of more than 5000 years of application, it can be used to treat a variety of common diseases, such as skin, lung, gastrointestinal system diseases, pain, wound, liver damage, joint pain and inflammation. Curcuma has a variety of health effects mainly due to its plant compound curcumin, which has super antioxidant properties and anti-inflammatory properties.

Studies have shown that curcumin is a powerful immune regulator that can regulate the activity of T cells, which are mainly responsible for cell-mediated immunity. In fact, curcumin has a wide range of immunomodulatory activities on T cells, macrophages, neutrophils, natural killer cells, dendritic cells will have an impact. In addition to these activities of curcumin, the anti-inflammatory activity of curcumin can also affect and down regulate some proinflammatory molecules, such as NFkB, tumor necrosis factor (TNF), interleukin and other chemokines.

In January 2020, the identity of turmeric food raw material was officially approved as a drug food homologous substance. Although it is only used as spice and condiment in food, more product application forms need to be developed.

Allicin

Allicin, a thiosulfite from garlic, has strong antibacterial activity and potential medicinal effects, and can be used to improve immunity.

The 2016 randomized double-blind controlled study of the University of Florida in the United States showed that the use of garlic extract supplements for 90 days could reduce the duration of colds and flu by 61%, reduce the symptoms of colds or flu by 21%, and reduce the lost workdays due to diseases by 58%. At the same time, garlic supplements can also enhance the function of immune cells, especially NK cells and gamma delta T cells.

In this study, the researchers recruited 120 healthy participants with an average age of 26 years, and randomly used 2.56g/day garlic supplement or placebo for 90 days. The results showed that the number of NK cells and T cells in the garlic supplement group increased significantly, and the number of symptoms, duration days and lost workdays due to illness of participants with cold and flu improved significantly. For the mechanism, the researchers said that allicin can increase the content of glutathione in cells and enhance the immune ability.

Broccoli

Broccoli is a variety of Brassica oleracea of Cruciferae, known as the "crown of vegetables".

The enzymatic hydrolysis product of glucosinolates in broccoli is mainly sulforaphane (sulforaphane, SF), which is the strongest class of isothiocyanates. It is considered to be the strongest anti-cancer ingredient found in vegetables so far.

In 2015, a study showed that high and low doses of sulforaphane could significantly improve the thymus index and spleen index reduced by cyclophosphamide (Cy), suggesting that sulforaphane could protect and promote the recovery of immune organs inhibited by Cy to a certain extent. In the experiment, peritoneal macrophage phagocytosis was selected as the indicator of non-specific immune function, hemolysin test as the specific humoral immune indicator, and lymphocyte transformation as the cellular immune indicator to observe the regulatory effect of two different doses of sulforaphane on the immune function of immunosuppressed mice model. The results suggested that high and low doses of sulforaphane could increase the phagocytic percentage and index of peritoneal macrophages, promote the formation of hemolysin, and high doses of sulforaphane could significantly stimulate the transformation of lymphocytes. The immune excitatory effect of high dose sulforaphane is strong, while that of low dose group is relatively weak. It is believed that the immune protective effect of sulforaphane is positively related to the dose, and the immune excitatory effect will be enhanced when the dose is increased.

The water extract of broccoli seed is a new food material approved by China.

Lycopene

Known as "plant gold", it has been proved by research that it has strong antioxidant capacity, which is about 100 times that of vitamin E. Lycopene not only has obvious effects in anti-aging, anti-cancer and enhancing human immunity, but also helps prevent and treat high cholesterol and hyperlipidemia in cardiovascular disease prevention. It is said that oral administration of natural lycopene can reduce serum cholesterol to 5 Less than 2mmol/L is conducive to slowing down the development of cardiovascular diseases.

Inhibiting the overexpression of adhesion molecules by inhibiting NF kB signal may be one of the main mechanisms of carotenoids in reducing the adhesion of inflammatory leukocytes to endothelial cells. In 2012, a study found that lycopene and lutein can improve the function of endothelial cells and reduce the inflammatory NF kB signal of endothelial cells, which is the first in-depth study on the mechanism of natural tomato products playing an active role in endothelial cells.

Eurycoma longifolia

Eurycoma longifolia comes from the roots of a tree native to Malaysia, Thailand and Indonesia. In 1999, it was called "Asian Viagra" by Newsday Times. Dongge Ali can enhance male sexual desire, replenish energy, reduce weight, and improve competitive status.
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