Scutellaria Baicalensis Extract Introduce

Scutellaria baicalensis extract

The pale yellow powder obtained by extracting and drying Scutellaria baicalensis

This product is a light yellow powder extracted and dried from Scutellaria baicalensis; Mild qi, bitter taste. It can be used in both medicine and cosmetics, and is a good functional cosmetic ingredient.

Chinese name: Scutellaria baicalensis extract

Explanation: The light yellow powder obtained by extracting and drying

Usage: Raw materials for beauty and cosmetics

Storage: Sealed, dark, and stored in a cool and dry place

Appearance: Powder

Odor: slightly bitter

Product Introduction

【 Source 】 Scutellaria baicalensis Georgi (Lamiaceae) is the dry root of Scutellaria baicalensis Georgi (Lamiaceae), a plant in the family Lamiaceae. It is widely distributed in China, with provinces such as Heilongjiang, Jilin, Liaoning, Henan, Hebei, Shandong, Sichuan, Yunnan, Shanxi, Shaanxi, Gansu, and Inner Mongolia being the production areas

【 Identification 】 Take a small amount of this product, add 2ml of water, and add 1 drop of sodium hydroxide test solution. The solution turns orange yellow. Add dilute acetic acid to make the color of the solution fade. Then add 1 drop of 5% zirconium oxychloride solution. The solution turns yellow, but the color does not fade with dilute hydrochloric acid.

【 Usage 】 It can be used in both medicine and cosmetics, and is a good functional cosmetic raw material.

[Content] 10% -90%

The shelf life is 2 years, provided that it meets storage requirements.

[Usage and Dosage] For the raw materials of other formulations, the dosage is determined according to different uses.

heavy metal

Microorganism

Functional effects

Clearing heat and dampness, purging fire and detoxifying, stopping bleeding, and ensuring safe pregnancy. Used for damp heat, summer heat, chest tightness and nausea, damp heat and fullness, diarrhea, jaundice, lung heat and cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, swelling and sores, and fetal restlessness.

pharmacological action

(1) Anti inflammatory and anti allergic reactions. Baicalin and baicalin have a relieving effect on isolated tracheal allergic contractions in guinea pigs and overall allergic asthma in animals, and are synergistic with ephedrine. The phosphate of glycosides has a stronger effect than sodium sulfate. Baicalin can inhibit Schultz Dale reactions in the isolated trachea and ileum, and also inhibit passive skin allergic reactions and histamine skin reactions in guinea pigs. In terms of anti allergic reactions, glycosides have a stronger effect than glycosides. The anti allergic reaction of Scutellaria baicalensis is caused by damaging the enzyme activation system of mast cells, inhibiting the release of allergenic mediators, and therefore not producing allergic reactions. In addition, it also has a direct relaxing effect on smooth muscle itself. Both baicalin and baicalin can inhibit allergic edema and inflammation, and both can reduce the permeability of mouse ear capillaries. The latter can also prevent low-pressure induced pulmonary hemorrhage in mice.

⑵ Antibacterial effect Scutellaria baicalensis Georgi has a wide antibacterial spectrum. It has inhibitory effects on dysentery bacillus, diphtheria bacillus, pseudomonas aeruginosa, staphylococcus, streptococcus, pneumococcus and meningococcus in test tubes. The decoction used as throat spray is also effective for meningitis carriers. Even staphylococcus aureus, which has developed resistance to penicillin, is still sensitive to Scutellaria baicalensis Georgi Georgi. In vitro, it has inhibitory effect on imported tuberculosis, and reports vary. The decoction is effective on experimental tuberculosis in mice, but not in guinea pigs. In vitro, it has an inhibitory effect on the PR8 strain of influenza virus. After mice are infected with the virus, it can reduce lung damage and prolong their survival time. It also has inhibitory effects on various skin pathogenic fungi in vitro and can kill Leptospira.

(3) Early reports on antipyretic effects showed that intravenous injection of 4-6 milliliters of 6% Scutellaria baicalensis extract had antipyretic effects on rabbits with fever caused by vaccines. However, in the future, some people have used high-dose Scutellaria baicalensis decoction (which is 4-30 times larger than the amount of Scutellaria baicalensis extract injected intravenously) orally or intramuscularly, but it has not been confirmed to have antipyretic effects. Intravenous injection has a slight antipyretic effect, which is similar to intravenous injection of physiological saline, 5 grams/kg of Scutellaria baicalensis cannot alleviate fever in rabbits caused by hot puncture. However, intraperitoneal or intravenous injection of baicalin and oral administration of baicalin decoction can alleviate fever in rabbits caused by vaccines or yeast. The above research results are inconsistent, possibly due to the fact that there are many plant sources that have not been pharmacognostically tested, the variety is chaotic, and intravenous injection of crude drugs can affect blood pressure and also interfere with antipyretic effects. Therefore, further research is needed to determine whether Scutellaria baicalensis has antipyretic properties. Huangqin extract has no cooling effect on rabbits.

(4) Hypotension and diuretic effects: Huangqin tincture, infusion, decoction, alcohol or water extract, baicalin can all have a hypotensive effect on anesthetized dogs, cats, rabbits by intravenous, intramuscular injection or enema. Oral infusion can lower the blood pressure of normal and chronic renal hypertensive dogs, while tincture can restore the blood pressure of neuropathic hypertensive dogs to normal. The antihypertensive effect of oral infusion is best in Yunnan, followed by Hebei, and worse in northwest. The hypotensive principle of Scutellaria baicalensis is believed to directly dilate blood vessels or act on vascular receptors, reflexively causing hypotension. Scutellaria galericulata, a plant of the same genus as Scutellaria baicalensis, has no antihypertensive effect.

In acute diuretic experiments, baicalin has the strongest effect, followed by baicalin, baicalin is poor, baicalin alcohol extract and decoction (normal humans and rabbits) also have diuretic effects.

The effect of Scutellaria baicalensis and Sanhuang preparations (Huanglian: Scutellaria baicalensis: rhubarb 1:1:1) on blood lipids and blood sugar has no effect on the ratio of total cholesterol to total phospholipids in the serum of normal rabbits, but it can reduce this ratio in rabbits after 7 weeks of raising cholesterol. The ratio of this ratio in thyroidectomy rabbits can also be reduced by Sanhuang preparations. Scutellaria baicalensis can cause a mild increase in blood sugar.

(6) Gallbladder promoting and antispasmodic effects: Scutellaria baicalensis decoction and ethanol extract can increase the excretion of bile in dogs and rabbits. Baicalin has a more significant effect than Scutellaria baicalensis, while baicalin has no effect. Baicalin increases bilirubin (compared to the control group) in rabbits with total bile duct ligation within 1-6 hours, but decreases after 24-48 hours. Huangqin tincture and decoction have a significant inhibitory effect on the in situ intestinal tract. The tincture can counteract the intestinal motility enhancement caused by pilocarpine, and cutting off the vagus nerve does not affect its effect. The potency of antispasmodic effect was determined using the small intestine segment of mice, and baicalin only has a weak antispasmodic effect, while baicalin has no antispasmodic effect.

(7)Sedative effect: Baicalin can inhibit spontaneous activity in mice, and the intensity of the effect depends on the dosage. Huangqin decoction can inhibit positive conditioned reflex in mice, which may be due to its strengthening of cortical inhibition process. It can be used for hypertension caused by increased nerve excitation and insomnia.

(8 )Other effects: Intravenous injection of Huangqin rhizome tincture can eliminate the symptoms of tonic spasms in frogs, cats, and dogs poisoned with strychnine, and prevent animals from dying. Baicalin and glucuronic acid can reduce the mortality rate of mice caused by strychnine poisoning by about 2.5 times. From the measurement of liver glycogen content in carbon tetrachloride poisoned mice, the glucuronic acid group had a higher content, followed by baicalin, and baicalin had the lowest content.

Toxicity: Scutellaria baicalensis has extremely low toxicity. When the decoction is given to rabbits by gavage and the alcohol extract is injected intravenously, the activity of the mice is weakened. When the Scutellaria baicalensis extract is given to dogs by gavage for 8 weeks, no toxic reactions are observed. If 2 grams/kg of Scutellaria baicalensis extract is injected intravenously into healthy rabbits, they first appear calm and then die, indicating that intravenous injection is much more toxic than oral administration. Extracts of Scutellaria baicalensis can significantly reduce the total white blood cell count of normal rabbits in a short period of time by intramuscular and intravenous injection.

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