Wolfberry powder

Wolfberry powder

A new generation of Lycium barbarum powder rich in Lycium barbarum acid

Wolfberry, wolfberry has always been a national tonic saint. It is favored for its functions of nourishing the liver and kidney, benefiting the essence and eyes, nourishing blood, and enhancing people's immunity. Modern pharmacological research shows that Lycium barbarum polysaccharides have the functions of improving immunity, anti-aging, anti-tumor, scavenging free radicals, anti fatigue, anti radiation, protecting liver, protecting and improving reproductive function.

However, another natural active component of Lycium barbarum - Lycium barbarum acid has been ignored and has not been effectively concerned and developed. Lycium barbarum acid is a new stable VC derivative found from Lycium barbarum species. Existing in vivo and in vitro experimental studies show that Lycium barbarum acid has certain free radical scavenging and antioxidant capacity. Moreover, compared with L-ascorbic acid, Lycium barbarum acid has a more mild and lasting antioxidant effect and higher antioxidant activity.

Natural stable L-ascorbic acid derivatives

Lycium acid can be directly absorbed by the intestines, enter the blood, and pass through β- The hydrolysis of glucosidase releases L-ascorbic acid, which plays a role in scavenging free radicals and antioxidation.

Antioxidant effect of Lycium barbarum acid

The antioxidant activity of Lycium barbarum acid was significantly higher than that of L-ascorbic acid and α- Ascorbic acid glucoside, which takes a longer time to remove free radicals, has the effect of L-ascorbic acid slow release. The results of in vitro antioxidant experiments showed that compared with L-ascorbic acid, Lycium barbarum acid had stronger ability to scavenge DPPH and hydrogen peroxide, and could control the hemolysis caused by hydrogen peroxide. At the same time, Lycium barbarum acid had the same ability to scavenge hydroxyl radicals as L-ascorbic acid, and its ability to scavenge nitrite was weaker than L-ascorbic acid. Further in vivo antioxidant experiments showed that Lycium barbarum acid could protect the liver of mice from acute liver injury caused by carbon tetrachloride, and significantly reduce the levels of alanine aminotransferase and aspartate aminotransferase in serum.

Hypoglycemic effect of Lycium barbarum acid

Effect of Lycium acid on Saccharomyces cerevisiae source α- Glucosidase has obvious competitive inhibitory activity. The results of in vitro enzyme inhibitory activity showed that Lycium acid α- The inhibition rate of glucosidase was positively correlated with the concentration, and its IC50 value (0.98mmo1/l) was less than that of acarbose (4.54mmo1/l). This shows that the inhibitory capacity of Lycium barbarum acid is higher than acarbose, and it has the development potential of hypoglycemic drugs.

In addition, studies have shown that Lycium acid combines with the source of Saccharomyces cerevisiae α- The three main amino acid active sites of glucosidase, asp214, glu276 and asp349, were competitively inhibited α- Glucosidase activity. In vivo experiments in mice also showed that Lycium barbarum acid could improve the postprandial blood glucose of normal mice and diabetes mice. Normal mice taking starch were fed with Lycium barbarum acid, and the blood glucose rise rate was only 20% at 30min, and returned to the fasting blood glucose level after 120min. Diabetes model mice taking maltose were fed with Lycium barbarum acid, and the blood glucose rise rate was only 10% at 30min, and fell to the fasting blood glucose level after 80min. Diabetes model mice taking starch were fed with Lycium barbarum acid, and the blood glucose rise rate was 18% at 30min, and fell to the fasting blood glucose level after 60min. Therefore, Lycium barbarum acid can better control the postprandial blood glucose level.

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