Pycnogenol+Bilberry Extract, A New Natural Solution For Eye Health

Pycnogenol+Bilberry Extract, A New Natural Solution For Eye Health

According to the data of the World Health Organization (WHO), more than 2.2 billion people around the world are suffering from visual impairment, and at least half of them suffer from eye diseases that can be prevented or have not been resolved.

In 2014, WHO and the International Agency for the Prevention of Blindness implemented a global action plan entitled "Vision 2020: the right to see". The goal of this initiative is to raise people's awareness of avoidable blindness and reduce blindness by 25% by 2020. Set up regional and national activities such as World Glaucoma Week to help solve the problem of global vision impairment and promote extensive support activities.

Glaucoma has become a common eye disease

Glaucoma is the third most common cause of blindness in the world, after cataract and uncorrected refractive error. In addition, glaucoma is a group of eye diseases that damage the optic nerve, and the health of the optic nerve is crucial to good vision. Such loss

The harm is usually caused by the increase of intraocular pressure (IOP) or the decrease of blood flow (OBF) caused by abnormally high intraocular pressure, which are considered as the main risk factors for the treatment of glaucoma.

It is reported that the damage caused by glaucoma is irreversible. Therefore, lowering intraocular pressure is the only method proven to avoid irreversible injury. Treatment may include prescription eye drops, oral medication, or surgery. With the increasing interest of consumers in natural alternatives, oral supplements are becoming more and more popular among consumers seeking natural alternatives.

Pycnogenol+blueberry extract: a new method for eye health

Dr. Franziska WNeichmann, Manager of Science Communication and Product Development Department of Hofa Research, Switzerland, said that Mirtogenol is a patent combination of Mirtoselect (bilberry extract) and Pycnogenol Pycnogenol (French marine pine bark extract), which is a nutritional method developed specifically to solve eye health.

In several studies, Pycnogenol has been proved to have a positive impact on eye health by strengthening retinal capillaries, and maintaining healthy retinal capillaries helps to control the leakage of fluid and blood into the retina. At the same time, bilberry extract Mirtoselect also has a positive impact on eye health by improving the tear secretion and plasma antioxidant potential of patients with dry eye disease (DED).

Support of clinical experimental data

In five clinical studies of more than 200 patients, Mirtogenol was found to have a significant effect on intraocular pressure (IOP) and ocular blood flow (OBF).

A preliminary clinical study of 38 asymptomatic patients with high intraocular pressure showed that the intraocular pressure (in mmHg) decreased significantly after 2 months of supplementation with Mirtogenol. After 3 months, IOPs were significantly lower than those in the control group. At the same time, the IOPs of 19 of 20 patients taking Mirtogenol decreased. After 2 months, the effects of different ophthalmic arteries in the systolic and diastolic phases on ocular blood flow were similarly improved.

Compared with the baseline group and the control group, the arterial blood flow velocity increased significantly after 3 months of supplementation with Mirtogenol, but no change was found in the blood flow velocity. For a total of 6 months, the subjects were supplemented with two Mirtogenol capsules (containing 40 mg pycnogenol and 80 mg Mirtoselect) every day. This study shows that Mirtogenol is a safe preventive solution that can reduce the risk of symptomatic glaucoma by controlling intraocular pressure and improving eye blood flow.

Mirtogenol combined with drug assistance, 1+1>2

Another 6-month study involved 79 patients with asymptomatic high intraocular pressure, and studied the effect of lower doses of Mirtogenol (40mg Pycnogenol and 80mg Mirtoselect) on the intraocular pressure of patients with latanoprost eye drops. Latanoprost is a drug for the treatment of elevated intraocular pressure, including high intraocular pressure and open-angle glaucoma. It is a kind of prostaglandin analogue, which can increase the outflow of water sample in the eye

In this study, some patients also used Mirtogenol in addition to latanoprost eye drops. The researchers found that Mirtogenol increased the intraocular pressure of latanoprost by 18%, and the blood flow in diastole and systole increased by 40% and 9% respectively. This study shows that after 6 weeks, regular combined intake of Mirtogenol and latanoprost can have beneficial effects on eye health, even better after 6 months of supplementation.

A study aimed at 88 patients with asymptomatic intraocular hypertension evaluated the effects of three months' supplementation of Mirtogenol (2 capsules per day) and traditional intraocular pressure lowering drugs (doxolol or latanoprost eye drops) on retinal microcirculation parameters and oxidative stress. After 6 weeks, the study showed that the supplementation of Mitogenol and latanoprost had positive clinical effects on intraocular pressure and blood flow.

Another 6 weeks later, at the end of the study, 58.1% of the subjects who received the treatment of Mirtogenol and latanoprost had normal intraocular pressure (compared with 41.4% of the patients who only received latanoprost). Compared with the baseline, the level of oxidative stress (measured by plasma free radicals) of Mirtogenol supplementation decreased by 17%.

Compared with the patients who did not use dietary supplements, the eye blood flow in the treatment group increased by 63% and 24% in the diastole and systole, respectively. In addition to the standard ophthalmic treatment, the supplement of Mirtogenol can improve the microcirculation parameters of the eye faster and more effectively than the single treatment without supplement, and may help to reduce the intraocular pressure to the normal level.

A placebo-controlled, prospective, double-blind, randomized study in 2017 investigated the effect of Mirtogenol supplementation on retinal nerve fiber layer (RNFL) thickness and visual field changes. 41 patients with primary open-angle glaucoma were treated with Mirtogenol for 2 months on the basis of taking glaucoma drugs, and the intraocular pressure was controlled.

The mean deviation of visual field in Mirtogenol group increased by 29.6% after 2 months; In the placebo group, it decreased by 6.9%. The average deviation of visual field decreased by 1.4% every month, which indicates that glaucoma has corresponding progressive changes. This study shows that Mirtogenol's further beneficial effect on eye health is a part of solving the risk factors related to glaucoma.

A new study in 2021 analyzed the effect of reducing intraocular pressure of 18 Japanese patients (29 eyes) with elevated intraocular pressure by taking Mirtogenol. In addition to individual anti-glaucoma drugs, these patients were also supplemented with Mirtogenol (40mg Pycnogenol and 90mg Mirtoselect). After 4 weeks, the IOPs of patients decreased significantly by 8.7%, which indicates that Mirtogenol has a good effect on improving the main risk factors of glaucoma.

Andy Biotech nology also provides herbal formulas to cosmetics customers, health food customers and food customers around the world. Please contact WhatsApp for more information 0086-15029046321 or sales@andybiotech.com.