Hop extract

Is There Any Side Effect Of Rapid Relief Of Arthritis Pain? How Does Hops Defeat Massive Competitors?

Joint discomfort is a global health problem. According to the recent statistics of the United States Centers for Disease Control and Prevention (CDC), there are 52.5 million adults with arthritis diagnosed by doctors in the United States. By 2040, this number is expected to rise to 78 million, equivalent to more than one quarter of Americans suffering from arthritis. The survey shows that many people may have been quietly dealing with this situation.

As this disease will continue to increase in the coming decades, there is a great need for a treatment method to help people reduce joint pain without causing side effects caused by existing treatment methods. Hop extract may be the choice that can meet both requirements.

Side effects&traditional therapy with slow effect

Non-drug intervention, such as physical therapy and weight loss plan, is the primary means for many arthritis patients to reduce their symptoms. In the long run, these methods can effectively reduce joint discomfort. In the short term, many people also have to rely on drug intervention to alleviate immediate pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, are widely used. Others turn to combined health products, such as glucosamine.

However, neither of these two treatments can guarantee safe and rapid relief of mild pain. NSAIDs alleviate discomfort by inhibiting cyclooxygenase or COX enzyme, which is an enzyme that reduces inflammation by blocking the synthesis of thromboxanes and prostaglandins. This approach can treat inflammation while relieving pain, which is a recognized method to relieve discomfort. However, because aspirin and ibuprofen can inhibit COX-1 and COX-2 enzymes at the same time, they will also hinder the process of protecting the inner wall of the gastrointestinal tract, leading to adverse reactions.

The shortcomings of non-selective COX inhibitors have pushed the industry and the patients it serves in two directions. One method is to develop substances that work on COX-2 but do not work on COX-1, that is, to provide analgesic effect without causing gastrointestinal discomfort. Among these products, the most famous one is Vioxx. Although it will not cause gastrointestinal discomfort, it will cause heart discomfort. Fish and bear's paw cannot have both. Another method is to take joint supplements such as glucosamine, but research shows that these products need 8 weeks or more to relieve joint discomfort and can not hydrolyze near thirst.

Natural selection, hop extract

A clinical trial took Perluxan as the research object, and found that it can relieve arthritis quickly, safely and effectively. It is reported that Perluxan is a plant preparation derived from the female cone of hops. The application of hops in the medical field has a precedent for a long time, but its potential to relieve mild pain was only revealed in a joint study in the late 1990s.

In this study, the researchers reviewed the literature of 230 plant ingredients to find natural ingredients that may be used as joint health and relieve mild pain. After layer by layer screening, 20 candidate ingredients entered the preclinical test stage. Finally, one kind of success

It stands out as concentrated hop resin extract. Researchers found that this extract contains high levels of alpha acid, a compound that makes beer bitter and is believed to have the characteristics of alleviating pain.

A glass of hops beer usually contains about 3 mg of alpha acid. A daily dose of Perluxan contains more than 300 mg of alpha acid, equivalent to 100 bottles of beer. Obtaining these amounts of alpha acid requires the use of supercritical carbon dioxide extract, without solvent. This extraction method can retain high concentration of active substances without extracting other compounds that may be active ingredients. Importantly, when tested in the Caco-2 cell line used for the intestinal b-cell model,

The results show that the alpha acid obtained by this method has good solubility and bioavailability.

These studies show that hops extract is the most promising of the 20 candidate ingredients identified in the literature search, so the project has entered the next stage, namely William Harvey Modified Whole Blood Assay. This test is considered as the gold standard for evaluating COX activity and product selectivity.

Finally, Perluxan was proved to be able to moderately inhibit COX-2 and COX-1, which increased the hope of researchers that it can relieve pain without the side effects of Wanluo or non-selective non-steroidal anti-inflammatory drugs such as aspirin and ibuprofen. If Perluxan completely inhibits COX-2, it will cause the adverse reactions caused by Vioxx. Similarly, moderate or greater inhibition of COX-1 means that gastrointestinal side effects associated with non-selective COX inhibitors will occur.

If Perluxan is in COX-2, it will cause adverse reactions caused by Vioxx. Similarly, moderate or greater inhibition of COX-1 means that it will produce gastrointestinal side effects related to non-selective COX inhibitors.

Clinical safety/effectiveness data

One group received a single dose of 400 mg of ordinary painkillers, the other group received a soft gel containing 450 mg of hops resin, and the last group received a capsule containing the resin powder. Both hops resins contain 150 mg of alpha acid.

Within 9 hours after taking the drug, the COX-2 level decreased at each stage of the trial. COX-2 is a part of the key analgesic pathway, which indicates that the effect of hop resin on discomfort symptoms may be similar to that of common analgesic drugs. The next step is to evaluate the effect of each treatment on COX-1, an enzyme involved in protecting the gastrointestinal tract. Although commonly used painkillers have significant effects on COX-1 - the level of COX-1 drops to 40% of the baseline - hop extract only causes a slight decrease in COX-1 level.

The results also showed that the hops resin soft gel preparation had a faster onset rate than the powder capsules. The researchers attribute this phenomenon to the soft gel formula, which uses the resin in its natural state rather than the powder needed to manufacture capsules. This result encourages researchers to advance the soft gel formula to the next development stage. This is a double-blind placebo-controlled randomized trial involving 36 people, which aims to evaluate the efficacy of Perluxan for people who occasionally feel discomfort in their knees.

Subjects completed the Western Ontario McMasters Osteoarthritis Index 5-item symptom evaluation questionnaire before the study began. Participants were asked to stop taking NSAIDs, but were allowed to use acetaminophen twice a week as a rescue drug if necessary. Two-thirds of the subjects were randomly assigned to take 1 g or 2 g of Perluxan daily, while the rest of the subjects were given placebo. These treatments were followed and observed by researchers for 14 days, and tested shortly after the initial dose to evaluate the rapid action performance of Perluxan.

Subjects who took 2 grams of Perluxan had a significant improvement in pain when walking on a flat road within two hours. Although there was no statistically significant change in pain perception of subjects taking 1 g of Perluxan, there was also a positive trend. In the next few days, the pain of the two groups of subjects taking Perluxan was significantly improved when walking on a flat road. This treatment can also relieve the pain of the subjects when they are in bed, sitting or lying down, and when they walk upright or go up and down stairs.

One of the 24 subjects in the Perluxan group used acetaminophen as a rescue drug, while three of the 12 subjects in the placebo group used acetaminophen. The subjects who took acetaminophen while taking Perluxan belong to the 2-gram dose group, and their performance is not better than that of the 1-gram group from multiple indicators. One adverse event occurred in the 2g experimental group: slight and intermittent burping. Researchers speculate that this may be related to experimental intervention. Blood tests before and after the intervention showed that Perluxan was well tolerated.

Fill the important gap of joint discomfort

The results of clinical trials have proved that hops extract can fill the gap in the field of mild pain relief. Importantly, preclinical and clinical data show that it will not cause COX-1 related complications, which will destroy the efficacy of NSAIDs and lead to gastric ulcer and bleeding in some people taking NSAIDs.

Equally important, clinical trials have shown that hops can rapidly combat discomfort and continuously improve joint function and quality of life. Glucosamine, chondroitin and other dietary supplements do not provide this fast-acting analgesic effect. In view of the hundreds of millions of patients with joint discomfort worldwide, this is a treatment method that many people are interested in.

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