Olive Leaf Extract, Tthe "Disguiser" Of Immune Health
Olive Leaf Extract, Tthe "Disguiser" Of Immune Health
Immune health is undoubtedly the focus of the global market in 2020, whether from the health of consumers themselves or from the sudden novel coronavirus.
For ordinary consumers, the population of people who take immune health products in their daily lives is not large, unless they experience certain symptoms in their own bodies, most of the first choice is vitamin C. This epidemic has raised consumers' awareness of health and immune products to a new level, which is beneficial for both the industry and consumers themselves.
According to Market data of Persistence Market Research, the global immune health supplement market reached 14 billion US dollars in 2017 and is expected to reach 25 billion US dollars in 2025, with a compound annual growth rate of 7.0%. At the same time, a global consumer survey conducted by Kerry in 2019 shows that there is a great demand for immune health products in the world, which is more obvious in Asia. For example, 50% of the respondents in China said they had used immune health food in the past six months, and another 29% said they would consider using such products in the future.
At present, the most common immune health raw materials are vitamins and minerals. Traditional functional raw materials such as ginseng, Andrographis paniculata paniculata, medlar, ganoderma lucidum, garlic, echinacea, elderberry, mushrooms, etc. also continue to attract the attention of the market and consumers. Of course, there are many immune "stars", such as astaxanthin, Curcumin β— Glucan (typically yeast and euglena), bird's nest acid, probiotics, etc. In recent years, the concept of improving immune health by starting with Gut microbiota has become more popular, and related scientific research and new products are also constantly updated.
↓ Olive, a gift from the Mediterranean
Olive tree is a very ancient tree and a long-lived tree with strong growth ability. There are about 500 varieties of olive trees cultivated worldwide. Among the numerous olive tree varieties, Olive (01ea europaea) is currently the most commercially used in the world. It belongs to the evergreen tree of Olea, Oleaceae family. It is a woody oil plant and fruit tree species with rich olive oil. It is mainly distributed in Mediterranean countries. Greece, Italy, Tunisia and Spain are the concentrated producing areas. At present, it is cultivated in subtropical regions around the world, as well as in areas south of the Yangtze River in China.
As an important economic tree, Olive trees have commercial application value, which can be described as "treasure all over". First of all, Olive fruit can be directly eaten or processed, with the effect of "clearing the throat, benefiting the lung, promoting fluid production and detoxification". In China, Chinese olive (Olive) also belongs to the same family of medicinal and edible herbs. It belongs to the Qingguo genus of the Qingguo family, mainly consisting of two species: white olive and black olive. Fujian Province is the most distributed place, with a cultivation history of over 2000 years. Secondly, the oil of Olive fruit press is called "liquid gold" in the West, which is also known as olive oil.
In addition, olive leaves can be used for feed purposes and can also be made into tea. The leaves themselves contain various bioactive components, typical of which are olive saponins and olive polyphenols. The scientific research on olive leaf extract (derived from Olive) began with the isolation of a crystalline substance named "brucine" from it by the French Army colonel Yitian Palas, M.D. Subsequent research has continuously confirmed that olive leaf extract has effects on antibacterial, antioxidant, immune health and cardiovascular disease.
↓ Olive leaf extract with significant antibacterial properties
In the Mediterranean region, olive leaf extract has been used as folk medicine for hundreds of years to treat fever and other diseases such as malaria, which contains a large amount of antioxidant polyphenols. Olive polyphenols include Hydroxytyrosol, oleuropein, Verbascum thapsus, etc. Several health claims have been approved by the European Food Safety Commission. Scientific research has shown that olive saponins have strong antioxidant activity, especially as free radical scavengers, which can enhance SOD activity and have pharmacological effects such as anti-tumor and hypoglycemic effects.
In addition, researchers from the School of Life Sciences of Northwest Normal University found that olive leaf extract has strong antibacterial activity and can be used as a green and safe botanical antibacterial agent. It has strong antibacterial effect on Staphylococcus epidermidis, Staphylococcus aureus, and Escherichia coli (MIC 1mg/mL, MBC 2mg/mL). Its antibacterial effect on Bacillus cereus, Staphylococcus aureus, and tetracycline resistant Escherichia coli is better than Berberine hydrochloride. In addition, Lee et al found that oleuropicrin and Caffeic acid in olive leaf extract showed inhibitory effects on microorganisms, and the antibacterial effect of combined phenolic compounds was significantly higher than that of phenolic compounds monomer.
In addition, a recent study showed that the olive leaf extract from Euromed could inhibit the growth of Listeria monocytogenes monocytogenes, a Monocyte proliferating bacterium. Dr. Yanhong Liu and other researchers synthesized synthetic gold nanowires using bacterial flagella as a template. Gold nanowires are an efficient catalyst that can improve the efficiency of plant secondary metabolites as bacterial inhibitors. Researchers found that olive leaf extract can completely inhibit the growth of Listeria monocytogenes monocytogenes in Monocyte. In addition, gold nanowires have high electrocatalytic activity and have no mutagenic effect at the concentration used.
In an earlier study published, Dr. Yanhong Liu and others studied the antibacterial effect of olive leaf extract on major foodborne pathogens (including Listeria monocytogenes monocytogenes, Escherichia coli and Salmonella enterica). The research results indicate that at a concentration of 62.5mg/mL, olive leaf extract almost completely inhibits the growth of these three pathogenic bacteria. In addition, it can also inhibit the biofilm formation of Monocyte proliferating Listeria monocytogenes and Salmonella enterica, and reduce the cell viability of Monocyte proliferating Listeria monocytogenes.
Olive leaf extract has a good application prospect as an bacteriostatic agent to control Listeria monocytogenes monocytogenes in food. These foodborne pathogens usually exist in dairy products, vegetables and ready to eat food, and can survive and grow under harsh conditions such as low temperature. Therefore, eliminating these bacteria is a great challenge for the food industry.
↓ Olive leaf extract, traditional immunotherapy
In the early 20th century, olive saponins were first isolated and found to have medicinal value such as antibiotics, antifungal, antibacterial, and antiviral properties. Olive bitter glycoside can stimulate macrophage activity, promoting inflammatory response in the early stage of inflammation, killing bacteria and phagocytosis; On the other hand, in the later stage of inflammation, it inhibits the inflammatory response, promotes cell proliferation, and collagen deposition. Research has also shown that olive oil extract can help support the immune system, as its anti-inflammatory fatty acids play a role in different pathways of activating immune capable cells.
Recently, Spain Pharmactive Company launched a non transgenic olive leaf extract Isenolic brand product, which is mainly to help prevent seasonal virus infection and promote immune health. The standardized Elenoic Acid content is ≥ 4%, and the main role of this ingredient is to eliminate and inhibit disease bacteria, such as Shingles virus, influenza virus, etc. The company claims that the product can directly penetrate cells, prevent the entry of specific viruses, and effectively "suppress their lifecycle".
Elenolic acid is one of the most important secondary metabolites of olives, and it is a natural weapon of olive trees against plant pathogens. It contributes to the antibacterial and antiviral functions of olive leaves, and was determined by scientific research decades ago, specifically targeting type A and type B flow Sense of influenza A, B, and C. Many studies have shown that this compound has the ability to prevent and alleviate symptoms of viral and microbial infections, including shortening the duration of colds.
In addition, studies have found that Elenolic Acid can naturally inhibit Neuraminic acid glycosidase, which is a key enzyme in influenza viruses. It can penetrate cells and decompose viruses from the host cell membrane. In turn, this promotes its release, infecting new cells, and isenolic can prevent, as well as subsequent viral proliferation. Tests in cell lines that are particularly susceptible to influenza infection show that the virus's Neuraminic acid
The concentration of Isenolic required to reduce glycosidase activity by half (referred to as IC50) is only 171.5 μ G/ml.
It is reported that Isenolic olive leaf extract comes from olive trees growing in the Mediterranean region, and the entire extraction process is completely controllable and traceable. By utilizing ancestral technology, the quality and purity of the product can be guaranteed. Isenolic is a water-soluble raw material, which can be used in soft capsules, syrup, powder and Effervescent tablet, as well as in food and beverage products. This ingredient is non genetically modified, has no radiation, is not doped, and has halal and kosher properties.
↓ Increase body immunity, Australian newcomers prefer "olives"
Since ancient times, Mediterranean countries have continued the tradition of consuming olives. In fact, adhering to the Mediterranean diet with olive oil as the main ingredient can bring many health benefits, from promoting microbial health to reducing prenatal weight gain and diabetes, and even preventing hearing loss. In the past two years, olive oil has also been recognized and accepted by people in the domestic market, and Mediterranean diet has attracted the attention of fitness professionals and health groups. In contrast, olive leaf extract has a low market recognition in China, but it is very popular in Western countries, especially in Australia and New Zealand, making it one of the essential products for local immune health. Many brands have launched immune products containing this ingredient.
Healthy care is a high-end health food brand under Nature's Care Company. Nowadays, Healthy care has become a best-selling local brand, favored by every Australian family, with its presence in major pharmacies and supermarkets. HealthCare's olive leaf products mainly come in two types: oral liquid and tablet, with single or mixed formulations. The olive leaf oral liquid product contains 5000mg of olive leaf extract per 5ml, which is equivalent to 22mg of olive saponin. Olive leaf capsules contain 3000mg of olive leaf extract per capsule, which is equivalent to 50mg of oleuropein. The concentration in the capsule form is relatively high. There is also a tablet product that combines olive and propolis, which is more effective in combating influenza.
COMVITA is a well-known Manuka honey producer in New Zealand, and its related honey products have long been distributed in the Chinese market and have also received attention from consumers. Olive leaf extract is also one of the products, with exclusive olive tree plantations in Australia. The olive leaf extract products launched by the company do not contain artificially added oleuropein. The unique extraction system provides a combination of 12 key natural Antioxidant effect of polyphenols and natural phenols, which can provide a strong free radical scavenging capacity. Currently, olive leaf extract products are mainly targeted at immune health and cardiovascular health.
Vabori is a family brand in Australia that has its own exclusive organic planting base, achieving transparency and traceability throughout the entire process from planting, extraction, to production and research and development. This olive leaf extract product contains standardized olive saponins (5mg/mL), without gluten, and the product packaging does not contain BPA. It is reported that olive leaf extract not only enhances the body's immune system, helps reduce the duration and severity of colds and flu, but also helps promote cardiovascular circulation and antioxidant activity. As a major olive grower in Australia, Wellgrove is a health product brand based on olives, and the product formula is made from olive leaves grown in exclusive orchards. The company's Super Immune Olive Leaf Extract product mainly contains olive saponin, a strong antioxidant that is beneficial for immune and heart health. This product can be consumed directly or added to water, smoothies, fruit juices, and other products for mixed consumption.
As a leading global brand of infant and child nutrition products, Child Life specializes in providing nutritional solutions for infants and young children. Its immune health products include Echinacea, Vitamin C, and First Defense, which are also known as the "three carriages" of immune health. The main formula of the First Defense product is olive leaf extract, Hypericum perforatum extract, Larix gmelinii extract, zinc and colloidal silver, which is specially developed for children's immune health.
In addition, other health benefits of olive leaf extract include healthy aging and heart health. In many anti-aging skincare formulas, most of them contain olive leaf extract, which can provide beneficial health aging effects. At the same time, olive leaf extract has powerful antioxidant polyphenols. It contains hydroxytyrosine, which has been clinically proven to promote blood circulation, reduce the oxidation level of low-density lipoprotein cholesterol, and help prevent Atherosclerosis.
I believe that with the continuous deepening of scientific research and market layout, olive leaves, a plant with hundreds of years of application history, will continue to be recognized and excavated.
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