Clinical Discovery: Codonopsis pilosula Extract Helps in the Prevention and Control of Hypertension
Clinical Discovery: Codonopsis pilosula Extract Helps in the Prevention and Control of Hypertension
Recently, a study conducted by Seoul University in South Korea showed that Codonopsis lanceolate extract may help reduce systolic blood pressure in pre hypertensive patients. Scientists from Seoul University in South Korea stated that compared to the baseline and placebo groups, the experimental group supplemented with Codonopsis pilosula extract for 6 consecutive weeks significantly reduced systolic blood pressure and reduced inflammation and oxidative stress markers in pre hypertensive patients.
The study has been published in the journal "Plant Therapy Research", and it is reported that the current study for the first time shows that the ability of Codonopsis pilosula extract to prevent the development of hypertension (HTN) in pre hypertensive patients depends on baseline systolic blood pressure.
↓ Long application history
Codonopsis pilosula grows in Central Asia, East Asia, and South Asia, and has a long history of use in traditional medicine. It can produce a series of health effects, from respiratory health to lipid management to cognitive health. Meanwhile, this study provides more evidence for the potential health benefits of Codonopsis pilosula extract. A review published in 2017 in Plant Therapy Research pointed out that the plant contains a range of bioactive substances, including saponins, alkaloids, polyphenols, phenylethanolamines, and polyacetylene.
This new study recruited 80 hypertensive patients between the ages of 19 and 60 (with systolic blood pressure between 120 and 139 millimeters of mercury and diastolic blood pressure between 80 and 89 millimeters of mercury). All participants were randomly divided into two groups, one group taking 1000 milligrams of Codonopsis pilosula extract daily, and the other group taking a placebo for six weeks.
↓ Clinical data support
The research results showed that compared with the placebo group, subjects who received Codonopsis pilosula extract had a significant decrease in systolic blood pressure compared to the baseline level. In addition, although there was no overall difference in diastolic blood pressure between the two groups, a subgroup analysis of first-stage hypertension patients showed that taking Codonopsis pilosula extract could lower the diastolic blood pressure of these subjects compared to placebo.
Among patients classified as stage 1 hypertension, compared with the placebo group, the reduction of high sensitivity C-reactive protein (hs CRP, an inflammatory marker) and malondialdehyde (a marker of oxidative stress) in the Codonopsis pilosula group was significantly higher than that in the placebo group. Researchers have shown that treatment with Codonopsis pilosula has beneficial effects on both parameters in subjects with stage 1 hypertension, and reduces levels of malondialdehyde and hs-CRP, indicating a decrease in lipid peroxidation and inflammation.
The results of this study indicate that the ability of Codonopsis pilosula extract to prevent disease progression may involve inhibiting the risk of endothelial dysfunction and dyslipidemia in patients with elevated systolic blood pressure, but may involve reducing inflammation and oxidative stress in patients with stage 1 hypertension. That is to say, this extract may be more effective for patients with stage 1 hypertension and can prevent the development of hypertension in pre hypertension patients through different pathways, depending on the different types of systolic blood pressure.
However, further research is needed in the future to identify potential molecular mechanisms.
Function of Codonopsis pilosula extract:
1. Enhance immunity: Codonopsis pilosula extract contains rich polysaccharides and various active ingredients, which can promote the activity of immune cells, enhance the body's immune function, and enhance resistance.
2. Anti fatigue effect: Codonopsis pilosula extract can improve the energy metabolism of the human body, increase physical strength, alleviate fatigue, and improve work and learning abilities.
3. Improve sleep quality: Codonopsis pilosula extract has sedative and calming effects, can regulate nervous system function, improve sleep quality, and reduce insomnia and anxiety.
4. Promoting digestion: Codonopsis pilosula extract can increase the peristalsis of the gastrointestinal tract, increase the secretion of gastric juice and digestive enzymes, promote the digestion and absorption of food, and improve gastrointestinal function.
5. Prevention of aging: The various active ingredients in Codonopsis pilosula extract have antioxidant effects, which can eliminate free radicals in the body, reduce cell damage, and delay the aging process.
Application fields of Codonopsis pilosula extract:
1. Pharmaceutical preparations: Codonopsis pilosula extract can be made into oral liquid, capsules, granules and other forms of drugs, used for regulating immune function, improving fatigue, promoting digestion and other symptoms of treatment.
2. Health products: Codonopsis pilosula extract can be made into health products as an auxiliary product for supplementing nutrition, enhancing immunity, and regulating physical fitness.
3. Beverages: Codonopsis pilosula extract can be added to tea, coffee, or other beverages for drinking, which has the effect of refreshing and refreshing, alleviating fatigue, and increasing physical strength.
4. Beauty and skincare products: Codonopsis pilosula extract can be applied in beauty and skincare products, with antioxidant, moisturizing, and anti-aging effects, helping to improve skin quality and delay skin aging.
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