Immunoregulatory function of plant polysaccharides

Immunoregulatory function of plant polysaccharides

Immune regulation is the most important and main biological activity of plant polysaccharides. Plant polysaccharides promote the development of corresponding immune organs through multiple targets such as multiple immune organs, cells, cytokines, immune signal channels and mucous membranes, assist the activation of immune cells, regulate cytokine secretion, improve antibody level and activate complement system, so as to stimulate the maturation of various immune active cells of the body with multiple functions and factors. Differentiation and reproduction, so that the body's immune system to restore balance.

Lentinan can improve the immune function of the body by improving the immune function of cells and humoral immunity. The study found that lentinan can improve the immune system of breast cancer patients by affecting T lymphocytes and regulate the immune status of infiltrating lymph in tumor tissues.

Aloe polysaccharide is a large class of macromolecular compounds with different physiological functions. It is a grape mannan with acetylated mannose residues. As the most active substance in Aloe saccharides, it has different pharmacological effects and can improve the immune function of patients with Alzheimer's disease. Acetylated mannose increases T lymphocyte activity by about 50% through macrophage activation and T cell stimulation, thereby increasing immunity and reducing secondary infection.

The most significant pharmacological activity of ginseng polysaccharide is immune regulation. Ginseng has a long history of medicine in China. It has the functions of tonifying vital energy, solidifying and detoxifying, generating fluid, calming nerves and benefiting intelligence. At present, ginseng has become one of the best selling Chinese herbal medicines in the world. Modern pharmacological studies indicate that ginseng has pharmacological activities such as immune regulation, anti-cancer, anti cerebral ischemia, treatment of diabetes, prevention of atherosclerosis and anti-inflammatory. Its main active components are ginsenoside and ginseng polysaccharide, both of which show good biological activities in vitro.

Astragalus polysaccharide can regulate the local immune microenvironment of the uterus by affecting the uterine macrophages. Polygonatum Polysaccharide has a significant effect on the immune recovery of mice after exercise; Pine needle polysaccharide has immune promoting effect on both normal macrophages and LPS stimulated macrophages; Black Ganoderma lucidum polysaccharides participate in the immune and inflammatory responses of the intestinal tract in multiple ways and improve the immunity of the intestinal tract; Jujube polysaccharide can significantly reduce the inflammatory factors in cells and show strong anti-inflammatory activity, so as to avoid excessive immune response and frequent strong and lasting inflammatory reaction; The compound polysaccharide composed of Lentinus edodes polysaccharide, tremella polysaccharide, Poria cocos polysaccharide, Cordyceps polysaccharide and bamboo fungus polysaccharide can improve the immunity of mice caused by cyclophosphamide.

Therefore, plant polysaccharides can regulate the immune function of the body in various ways. With the improvement of modern technology, more kinds and purity of plant polysaccharides have been developed, so the bioavailability, function development and value of plant polysaccharides will be greatly improved.

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